Yes,
humility can be coupled with confidence if the confidence is in the Lord. Consider the contrast between the first line in Psalm 40:17 and the second. The first is a confession of such humility that it sounds as if the psalmist is defeated, but the second line is an expression of such comfort and hope that it grants him complete confidence in the Lord.
As for me, I am poor and needy,
but the Lord takes thought for me. (Psalm 40:17)
Poor and needy we may be, but it should be enough for us to know that the Lord takes thought for us. What could give us greater confidence and assurance than that?